Drug interactions
Tolterodine + Trazodone
Severity: Moderate
Tolterodine and Trazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trazodone has mild anticholinergic activity that can add to tolterodine's antimuscarinic effects. Dry mouth, constipation, and sedation may be more pronounced, particularly in older adults. Both drugs have also been associated with QT prolongation.
What this interaction means in plain words
Tolterodine and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Tolterodine belongs to Genitourinary; Trazodone belongs to Central Nervous System.
Why it happens
Additive antimuscarinic effects and additive QT-prolonging potential.
What to do
Monitor for anticholinergic effects and sedation, especially in elderly patients. Consider an ECG if other QT-prolonging risk factors are present.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tolterodine
Other interactions of Trazodone
- Arsenic trioxide + Trazodone Contraindicated
- Ibutilide + Trazodone Contraindicated
- Isocarboxazid + Trazodone Contraindicated
- Levoketoconazole + Trazodone Contraindicated
- Methylene blue + Trazodone Contraindicated
- Phenelzine + Trazodone Contraindicated
Frequently asked questions
Can I take Tolterodine with Trazodone?
MediHelp rates the interaction as moderate. Tolterodine and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Trazodone has mild anticholinergic activity that can add to tolterodine's antimuscarinic effects. Dry mouth, constipation, and sedation may be more pronounced, particularly in older adults. Both drugs have also been associated with QT prolongation.
How serious is the interaction between Tolterodine and Trazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic effects and sedation, especially in elderly patients. Consider an ECG if other QT-prolonging risk factors are present.
What other medicines interact with Tolterodine?
MediHelp also lists interactions of Tolterodine with, for example, Clarithromycin, Clozapine, Cobicistat. The full list is on the Tolterodine page.
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