Drug interactions
Tolterodine + Trimipramine
Severity: Moderate
Tolterodine and Trimipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trimipramine is a tricyclic antidepressant with substantial anticholinergic activity, which adds to tolterodine's effects. This raises the risk of urinary retention, constipation, dry mouth, confusion, and tachycardia. Both agents can also prolong the QT interval.
What this interaction means in plain words
Tolterodine and Trimipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Tolterodine belongs to Genitourinary; Trimipramine belongs to Central Nervous System.
Why it happens
Additive antimuscarinic effects and additive QT prolongation.
What to do
Monitor for anticholinergic toxicity and cognitive effects, and consider baseline and follow-up ECG in patients with cardiac risk factors. Consider an alternative bladder agent in older patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tolterodine
Other interactions of Trimipramine
- Disopyramide + Trimipramine Contraindicated
- Dofetilide + Trimipramine Contraindicated
- Ibutilide + Trimipramine Contraindicated
- Isocarboxazid + Trimipramine Contraindicated
- Pentamidine + Trimipramine Contraindicated
- Phenelzine + Trimipramine Contraindicated
Frequently asked questions
Can I take Tolterodine with Trimipramine?
MediHelp rates the interaction as moderate. Tolterodine and Trimipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Trimipramine is a tricyclic antidepressant with substantial anticholinergic activity, which adds to tolterodine's effects. This raises the risk of urinary retention, constipation, dry mouth, confusion, and tachycardia. Both agents can also prolong the QT interval.
How serious is the interaction between Tolterodine and Trimipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic toxicity and cognitive effects, and consider baseline and follow-up ECG in patients with cardiac risk factors. Consider an alternative bladder agent in older patients.
What other medicines interact with Tolterodine?
MediHelp also lists interactions of Tolterodine with, for example, Clarithromycin, Clozapine, Cobicistat. The full list is on the Tolterodine page.
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