Drug interactions
Topiramate + Ubrogepant
Severity: Moderate
Topiramate and Ubrogepant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Topiramate is a weak to moderate CYP3A4 inducer, which can lower ubrogepant concentrations and reduce its effectiveness for acute migraine. Ubrogepant labeling advises dose adjustment with CYP3A4 inducers.
What this interaction means in plain words
Topiramate and Ubrogepant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Topiramate belongs to Central Nervous System; Ubrogepant belongs to Central Nervous System.
Why it happens
Induction of CYP3A4 by topiramate increases ubrogepant metabolism.
What to do
Follow ubrogepant labeling for dosing with CYP3A4 inducers, using the higher initial dose where recommended. Monitor migraine response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Topiramate
Other interactions of Ubrogepant
- Clarithromycin + Ubrogepant Contraindicated
- Itraconazole + Ubrogepant Contraindicated
- Ketoconazole + Ubrogepant Contraindicated
- Posaconazole + Ubrogepant Contraindicated
- Ubrogepant + Voriconazole Contraindicated
- Apalutamide + Ubrogepant Major
Frequently asked questions
Can I take Topiramate with Ubrogepant?
MediHelp rates the interaction as moderate. Topiramate and Ubrogepant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Topiramate is a weak to moderate CYP3A4 inducer, which can lower ubrogepant concentrations and reduce its effectiveness for acute migraine. Ubrogepant labeling advises dose adjustment with CYP3A4 inducers.
How serious is the interaction between Topiramate and Ubrogepant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Follow ubrogepant labeling for dosing with CYP3A4 inducers, using the higher initial dose where recommended. Monitor migraine response.
What other medicines interact with Topiramate?
MediHelp also lists interactions of Topiramate with, for example, Benzhydrocodone / acetaminophen, Buprenorphine long-acting, Buprenorphine subdermal implant. The full list is on the Topiramate page.
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