Drug interactions
Topotecan + Trastuzumab deruxtecan
Severity: Major
Topotecan and Trastuzumab deruxtecan: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs cause neutropenia, so combining them can increase the frequency and severity of myelosuppression and febrile neutropenia. Trastuzumab deruxtecan also carries a risk of interstitial lung disease.
What this interaction means in plain words
Topotecan and Trastuzumab deruxtecan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Topotecan belongs to Oncology; Trastuzumab deruxtecan belongs to Oncology.
Why it happens
Additive myelosuppression from the topoisomerase I inhibitor payload and topotecan.
What to do
Avoid combining outside a clinical protocol, and monitor complete blood counts frequently. Interrupt or reduce doses for grade 3 or higher neutropenia, and consider growth factor support.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Topotecan and Trastuzumab deruxtecan, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Topotecan
- Adenovirus types 4 and 7 live + Topotecan Contraindicated
- Amiodarone + Topotecan Major
- Cisplatin + Topotecan Major
- Cobicistat + Topotecan Major
- Cyclosporine + Topotecan Major
- Cyclosporin + Topotecan Major
Other interactions of Trastuzumab deruxtecan
Frequently asked questions
Can I take Topotecan with Trastuzumab deruxtecan?
MediHelp rates the interaction as major. Topotecan and Trastuzumab deruxtecan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs cause neutropenia, so combining them can increase the frequency and severity of myelosuppression and febrile neutropenia. Trastuzumab deruxtecan also carries a risk of interstitial lung disease.
How serious is the interaction between Topotecan and Trastuzumab deruxtecan?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining outside a clinical protocol, and monitor complete blood counts frequently. Interrupt or reduce doses for grade 3 or higher neutropenia, and consider growth factor support.
What other medicines interact with Topotecan?
MediHelp also lists interactions of Topotecan with, for example, Adenovirus types 4 and 7 live, Amiodarone, Cisplatin. The full list is on the Topotecan page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
