Drug interactions
Topotecan + Vemurafenib
Severity: Moderate
Topotecan and Vemurafenib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vemurafenib inhibits P-glycoprotein and may increase exposure to topotecan, particularly oral topotecan. This could increase myelosuppression.
What this interaction means in plain words
Topotecan and Vemurafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Topotecan belongs to Oncology; Vemurafenib belongs to Oncology.
Why it happens
Vemurafenib inhibits P-gp efflux transport of topotecan, increasing systemic exposure.
What to do
Avoid oral topotecan with vemurafenib; with IV topotecan monitor blood counts and reduce dose if toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Topotecan
- Adenovirus types 4 and 7 live + Topotecan Contraindicated
- Amiodarone + Topotecan Major
- Cisplatin + Topotecan Major
- Cobicistat + Topotecan Major
- Cyclosporine + Topotecan Major
- Cyclosporin + Topotecan Major
Other interactions of Vemurafenib
Frequently asked questions
Can I take Topotecan with Vemurafenib?
MediHelp rates the interaction as moderate. Topotecan and Vemurafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vemurafenib inhibits P-glycoprotein and may increase exposure to topotecan, particularly oral topotecan. This could increase myelosuppression.
How serious is the interaction between Topotecan and Vemurafenib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid oral topotecan with vemurafenib; with IV topotecan monitor blood counts and reduce dose if toxicity develops.
What other medicines interact with Topotecan?
MediHelp also lists interactions of Topotecan with, for example, Adenovirus types 4 and 7 live, Amiodarone, Cisplatin. The full list is on the Topotecan page.
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