Drug interactions
Tranylcypromine + Zolmitriptan
Severity: Contraindicated
Tranylcypromine and Zolmitriptan: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tranylcypromine inhibits MAO-A, which contributes to zolmitriptan metabolism, so zolmitriptan and its active metabolite accumulate. Together with additive serotonergic effects this raises the risk of serotonin syndrome and vasoconstriction. Concurrent use is contraindicated.
What this interaction means in plain words
Tranylcypromine and Zolmitriptan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Tranylcypromine belongs to Central Nervous System; Zolmitriptan belongs to Central Nervous System.
Why it happens
MAO inhibition reduces zolmitriptan clearance, and both drugs enhance serotonergic neurotransmission.
What to do
Do not combine; allow 2 weeks after stopping tranylcypromine before starting zolmitriptan. Use a non-triptan option for acute migraine.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Tranylcypromine
- 5-HTP + Tranylcypromine Contraindicated
- Amitriptyline + Tranylcypromine Contraindicated
- Amoxapine + Tranylcypromine Contraindicated
- Atomoxetine + Tranylcypromine Contraindicated
- Benzphetamine + Tranylcypromine Contraindicated
- Brimonidine + Tranylcypromine Contraindicated
Other interactions of Zolmitriptan
- Almotriptan + Zolmitriptan Contraindicated
- Dihydroergotamine intranasal + Zolmitriptan Contraindicated
- Dihydroergotamine + Zolmitriptan Contraindicated
- Eletriptan + Zolmitriptan Contraindicated
- Ergoloid mesylates + Zolmitriptan Contraindicated
- Ergotamine + Zolmitriptan Contraindicated
Frequently asked questions
Can I take Tranylcypromine with Zolmitriptan?
MediHelp rates the interaction as contraindicated. Tranylcypromine and Zolmitriptan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Tranylcypromine inhibits MAO-A, which contributes to zolmitriptan metabolism, so zolmitriptan and its active metabolite accumulate. Together with additive serotonergic effects this raises the risk of serotonin syndrome and vasoconstriction. Concurrent use is contraindicated.
How serious is the interaction between Tranylcypromine and Zolmitriptan?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine; allow 2 weeks after stopping tranylcypromine before starting zolmitriptan. Use a non-triptan option for acute migraine.
What other medicines interact with Tranylcypromine?
MediHelp also lists interactions of Tranylcypromine with, for example, 5-HTP, Amitriptyline, Amoxapine. The full list is on the Tranylcypromine page.
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