Drug interactions
Trazodone + Triptorelin
Severity: Moderate
Trazodone and Triptorelin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Triptorelin, as androgen deprivation therapy, may prolong the QT interval, and trazodone also has QT-prolonging potential. Together they may raise the risk of torsades de pointes, particularly in patients with other risk factors.
What this interaction means in plain words
Trazodone and Triptorelin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Trazodone belongs to Central Nervous System; Triptorelin belongs to Endocrine.
Why it happens
Additive QT prolongation, with androgen deprivation by triptorelin contributing to repolarization changes.
What to do
Consider baseline and periodic ECG monitoring and correct electrolyte abnormalities. Reassess the need for trazodone if QTc lengthens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Trazodone
- Arsenic trioxide + Trazodone Contraindicated
- Ibutilide + Trazodone Contraindicated
- Isocarboxazid + Trazodone Contraindicated
- Levoketoconazole + Trazodone Contraindicated
- Methylene blue + Trazodone Contraindicated
- Phenelzine + Trazodone Contraindicated
Other interactions of Triptorelin
Frequently asked questions
Can I take Trazodone with Triptorelin?
MediHelp rates the interaction as moderate. Trazodone and Triptorelin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Triptorelin, as androgen deprivation therapy, may prolong the QT interval, and trazodone also has QT-prolonging potential. Together they may raise the risk of torsades de pointes, particularly in patients with other risk factors.
How serious is the interaction between Trazodone and Triptorelin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider baseline and periodic ECG monitoring and correct electrolyte abnormalities. Reassess the need for trazodone if QTc lengthens.
What other medicines interact with Trazodone?
MediHelp also lists interactions of Trazodone with, for example, Arsenic trioxide, Ibutilide, Isocarboxazid. The full list is on the Trazodone page.
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