Drug interactions
Trazodone + Zuranolone
Severity: Major
Trazodone and Zuranolone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs cause sedation, and zuranolone already carries a boxed warning for impaired driving and CNS depression. Using them together can increase somnolence, dizziness and psychomotor impairment.
What this interaction means in plain words
Trazodone and Zuranolone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Trazodone belongs to Central Nervous System; Zuranolone belongs to Central Nervous System.
Why it happens
Additive CNS depression through pharmacodynamic synergism; zuranolone is a GABA-A positive modulator and trazodone is sedating.
What to do
Consider reducing the dose of zuranolone or trazodone if sedation develops, and counsel the patient not to drive or operate machinery for at least 12 hours after zuranolone. Monitor for excessive sedation.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Trazodone
- Arsenic trioxide + Trazodone Contraindicated
- Ibutilide + Trazodone Contraindicated
- Isocarboxazid + Trazodone Contraindicated
- Levoketoconazole + Trazodone Contraindicated
- Methylene blue + Trazodone Contraindicated
- Phenelzine + Trazodone Contraindicated
Other interactions of Zuranolone
- Alprazolam + Zuranolone Major
- Amobarbital + Zuranolone Major
- Apalutamide + Zuranolone Major
- Asenapine + Zuranolone Major
- Brexpiprazole + Zuranolone Major
- Butorphanol + Zuranolone Major
Frequently asked questions
Can I take Trazodone with Zuranolone?
MediHelp rates the interaction as major. Trazodone and Zuranolone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs cause sedation, and zuranolone already carries a boxed warning for impaired driving and CNS depression. Using them together can increase somnolence, dizziness and psychomotor impairment.
How serious is the interaction between Trazodone and Zuranolone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider reducing the dose of zuranolone or trazodone if sedation develops, and counsel the patient not to drive or operate machinery for at least 12 hours after zuranolone. Monitor for excessive sedation.
What other medicines interact with Trazodone?
MediHelp also lists interactions of Trazodone with, for example, Arsenic trioxide, Ibutilide, Isocarboxazid. The full list is on the Trazodone page.
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