Drug interactions
Trimethoprim + Ziprasidone
Severity: Moderate
Trimethoprim and Ziprasidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trimethoprim, especially combined with sulfamethoxazole, has been associated with QT prolongation and may add to ziprasidone's effect. Electrolyte shifts such as hyperkalemia can increase the arrhythmia risk.
What this interaction means in plain words
Trimethoprim and Ziprasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Trimethoprim belongs to Anti Bacterial; Ziprasidone belongs to Central Nervous System.
Why it happens
Possible additive QT prolongation; trimethoprim-related hyperkalemia may contribute.
What to do
Monitor ECG and serum potassium and magnesium if used together, particularly in patients with renal impairment or cardiac disease. Choose an alternative antibiotic where there are other QT risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ziprasidone
- Amiodarone + Ziprasidone Contraindicated
- Amitriptyline + Ziprasidone Contraindicated
- Arsenic trioxide + Ziprasidone Contraindicated
- Bedaquiline + Ziprasidone Contraindicated
- Chloroquine + Ziprasidone Contraindicated
- Citalopram + Ziprasidone Contraindicated
Other interactions of Trimethoprim
Frequently asked questions
Can I take Trimethoprim with Ziprasidone?
MediHelp rates the interaction as moderate. Trimethoprim and Ziprasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Trimethoprim, especially combined with sulfamethoxazole, has been associated with QT prolongation and may add to ziprasidone's effect. Electrolyte shifts such as hyperkalemia can increase the arrhythmia risk.
How serious is the interaction between Trimethoprim and Ziprasidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and serum potassium and magnesium if used together, particularly in patients with renal impairment or cardiac disease. Choose an alternative antibiotic where there are other QT risk factors.
What other medicines interact with Ziprasidone?
MediHelp also lists interactions of Ziprasidone with, for example, Amiodarone, Amitriptyline, Arsenic trioxide. The full list is on the Ziprasidone page.
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