Drug interactions
Trofinetide + Warfarin
Severity: Minor
Trofinetide and Warfarin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trofinetide is a weak CYP3A4 inhibitor, which could slightly raise exposure to the R-enantiomer of warfarin. The expected effect on INR is small because CYP3A4 is a minor pathway for warfarin.
What this interaction means in plain words
Trofinetide and Warfarin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Trofinetide belongs to Central Nervous System; Warfarin belongs to Cardiovascular.
Why it happens
Weak CYP3A4 inhibition may slightly reduce warfarin clearance.
What to do
Check INR after starting or stopping trofinetide and adjust warfarin only if the INR changes.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Warfarin
- Defibrotide + Warfarin Contraindicated
- Ketorolac + Warfarin Contraindicated
- Abciximab + Warfarin Major
- Acetylsalicylic acid + Warfarin Major
- Adagrasib + Warfarin Major
- Amiodarone + Warfarin Major
Other interactions of Trofinetide
Frequently asked questions
Can I take Trofinetide with Warfarin?
MediHelp rates the interaction as minor. Trofinetide and Warfarin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Trofinetide is a weak CYP3A4 inhibitor, which could slightly raise exposure to the R-enantiomer of warfarin. The expected effect on INR is small because CYP3A4 is a minor pathway for warfarin.
How serious is the interaction between Trofinetide and Warfarin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check INR after starting or stopping trofinetide and adjust warfarin only if the INR changes.
What other medicines interact with Warfarin?
MediHelp also lists interactions of Warfarin with, for example, Defibrotide, Ketorolac, Abciximab. The full list is on the Warfarin page.
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