Drug interactions
Tucatinib + Ulipristal
Severity: Major
Tucatinib and Ulipristal: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tucatinib is a strong CYP3A inhibitor and can raise ulipristal exposure. Ulipristal labeling advises against combining it with strong CYP3A4 inhibitors due to increased adverse effects.
What this interaction means in plain words
Tucatinib and Ulipristal can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Tucatinib inhibits CYP3A4, reducing the metabolism of ulipristal.
What to do
Avoid concurrent use where possible and choose a non-CYP3A-dependent alternative. If ulipristal is needed as a single emergency dose, counsel the patient and monitor for adverse effects.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Tucatinib
- Cisapride + Tucatinib Contraindicated
- Eletriptan + Tucatinib Contraindicated
- Ergotamine + Tucatinib Contraindicated
- Flibanserin + Tucatinib Contraindicated
- Ranolazine + Tucatinib Contraindicated
- Amobarbital + Tucatinib Major
Frequently asked questions
Can I take Tucatinib with Ulipristal?
MediHelp rates the interaction as major. Tucatinib and Ulipristal can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Tucatinib is a strong CYP3A inhibitor and can raise ulipristal exposure. Ulipristal labeling advises against combining it with strong CYP3A4 inhibitors due to increased adverse effects.
How serious is the interaction between Tucatinib and Ulipristal?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use where possible and choose a non-CYP3A-dependent alternative. If ulipristal is needed as a single emergency dose, counsel the patient and monitor for adverse effects.
What other medicines interact with Tucatinib?
MediHelp also lists interactions of Tucatinib with, for example, Cisapride, Eletriptan, Ergotamine. The full list is on the Tucatinib page.
Full monographs, dosing and an interaction checker in the MediHelp app
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