Drug interactions
Tucatinib + Venlafaxine
Severity: Moderate
Tucatinib and Venlafaxine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tucatinib is a CYP3A inhibitor and may raise venlafaxine exposure, but venlafaxine is mainly metabolized by CYP2D6, so the effect is likely modest. Higher venlafaxine levels could increase blood pressure and serotonergic adverse effects.
What this interaction means in plain words
Tucatinib and Venlafaxine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Tucatinib belongs to Oncology; Venlafaxine belongs to Central Nervous System.
Why it happens
Inhibition of CYP3A4 by tucatinib reduces the minor metabolic pathway of venlafaxine.
What to do
Monitor blood pressure and adverse effects of venlafaxine, and reduce the dose if toxicity appears. No routine dose change is needed in most patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Venlafaxine
- Isocarboxazid + Venlafaxine Contraindicated
- Methylene blue + Venlafaxine Contraindicated
- Phenelzine + Venlafaxine Contraindicated
- Procarbazine + Venlafaxine Contraindicated
- Rasagiline + Venlafaxine Contraindicated
- Safinamide + Venlafaxine Contraindicated
Other interactions of Tucatinib
- Cisapride + Tucatinib Contraindicated
- Eletriptan + Tucatinib Contraindicated
- Ergotamine + Tucatinib Contraindicated
- Flibanserin + Tucatinib Contraindicated
- Ranolazine + Tucatinib Contraindicated
- Amobarbital + Tucatinib Major
Frequently asked questions
Can I take Tucatinib with Venlafaxine?
MediHelp rates the interaction as moderate. Tucatinib and Venlafaxine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tucatinib is a CYP3A inhibitor and may raise venlafaxine exposure, but venlafaxine is mainly metabolized by CYP2D6, so the effect is likely modest. Higher venlafaxine levels could increase blood pressure and serotonergic adverse effects.
How serious is the interaction between Tucatinib and Venlafaxine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and adverse effects of venlafaxine, and reduce the dose if toxicity appears. No routine dose change is needed in most patients.
What other medicines interact with Venlafaxine?
MediHelp also lists interactions of Venlafaxine with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Venlafaxine page.
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