Drug interactions
Ublituximab + Vedolizumab
Severity: Moderate
Ublituximab and Vedolizumab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vedolizumab acts selectively on gut lymphocyte trafficking, while ublituximab depletes B cells systemically. Combined use may add to infection risk.
What this interaction means in plain words
Ublituximab and Vedolizumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ublituximab belongs to Miscellaneous; Vedolizumab belongs to Gastrointestinal Tract.
Why it happens
Additive immunosuppression from integrin-mediated gut-selective inhibition and CD20 B-cell depletion.
What to do
Monitor for infections and consider the long duration of B-cell depletion when combining or sequencing these drugs. Screen for hepatitis B before treatment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vedolizumab
- Natalizumab + Vedolizumab Contraindicated
- Baricitinib + Vedolizumab Major
- Certolizumab pegol + Vedolizumab Major
- Etanercept + Vedolizumab Major
- Golimumab + Vedolizumab Major
- Smallpox vaccine live + Vedolizumab Major
Other interactions of Ublituximab
Frequently asked questions
Can I take Ublituximab with Vedolizumab?
MediHelp rates the interaction as moderate. Ublituximab and Vedolizumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vedolizumab acts selectively on gut lymphocyte trafficking, while ublituximab depletes B cells systemically. Combined use may add to infection risk.
How serious is the interaction between Ublituximab and Vedolizumab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for infections and consider the long duration of B-cell depletion when combining or sequencing these drugs. Screen for hepatitis B before treatment.
What other medicines interact with Vedolizumab?
MediHelp also lists interactions of Vedolizumab with, for example, Natalizumab, Baricitinib, Certolizumab pegol. The full list is on the Vedolizumab page.
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