Drug interactions
Umeclidinium-vilanterol + Vemurafenib
Severity: Moderate
Umeclidinium-vilanterol and Vemurafenib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vemurafenib can prolong the QT interval and vilanterol may add to this and lower potassium. The combination raises arrhythmia risk, especially with other risk factors.
What this interaction means in plain words
Umeclidinium-vilanterol and Vemurafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Umeclidinium-vilanterol belongs to Respiratory; Vemurafenib belongs to Oncology.
Why it happens
Additive QT prolongation and beta-2 agonist-related hypokalemia.
What to do
Monitor ECG and electrolytes at baseline and during therapy. Correct electrolyte abnormalities and review therapy if QTc rises.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Umeclidinium-vilanterol
Other interactions of Vemurafenib
Frequently asked questions
Can I take Umeclidinium-vilanterol with Vemurafenib?
MediHelp rates the interaction as moderate. Umeclidinium-vilanterol and Vemurafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vemurafenib can prolong the QT interval and vilanterol may add to this and lower potassium. The combination raises arrhythmia risk, especially with other risk factors.
How serious is the interaction between Umeclidinium-vilanterol and Vemurafenib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and electrolytes at baseline and during therapy. Correct electrolyte abnormalities and review therapy if QTc rises.
What other medicines interact with Umeclidinium-vilanterol?
MediHelp also lists interactions of Umeclidinium-vilanterol with, for example, Aclidinium, Amiodarone, Amitriptyline. The full list is on the Umeclidinium-vilanterol page.
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