Drug interactions
Umeclidinium-vilanterol + Voriconazole
Severity: Moderate
Umeclidinium-vilanterol and Voriconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voriconazole can prolong the QT interval, and vilanterol may add cardiac stimulation and hypokalemia. Voriconazole also inhibits CYP3A4, which may raise vilanterol exposure.
What this interaction means in plain words
Umeclidinium-vilanterol and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Umeclidinium-vilanterol belongs to Respiratory; Voriconazole belongs to Anti Fungals.
Why it happens
Additive QT effects, plus CYP3A4 inhibition that may increase vilanterol exposure.
What to do
Monitor ECG, heart rate and potassium during co-therapy, especially with other QT risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Umeclidinium-vilanterol
Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Frequently asked questions
Can I take Umeclidinium-vilanterol with Voriconazole?
MediHelp rates the interaction as moderate. Umeclidinium-vilanterol and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Voriconazole can prolong the QT interval, and vilanterol may add cardiac stimulation and hypokalemia. Voriconazole also inhibits CYP3A4, which may raise vilanterol exposure.
How serious is the interaction between Umeclidinium-vilanterol and Voriconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG, heart rate and potassium during co-therapy, especially with other QT risk factors.
What other medicines interact with Umeclidinium-vilanterol?
MediHelp also lists interactions of Umeclidinium-vilanterol with, for example, Aclidinium, Amiodarone, Amitriptyline. The full list is on the Umeclidinium-vilanterol page.
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