Drug interactions
Umeclidinium-vilanterol + Vorinostat
Severity: Moderate
Umeclidinium-vilanterol and Vorinostat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vorinostat has been associated with QT changes and electrolyte disturbances, and vilanterol may add to cardiac effects. The combined risk is generally modest but relevant in at-risk patients.
What this interaction means in plain words
Umeclidinium-vilanterol and Vorinostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Umeclidinium-vilanterol belongs to Respiratory; Vorinostat belongs to Oncology.
Why it happens
Possible additive QT prolongation and beta-2 agonist-related hypokalemia.
What to do
Monitor ECG, potassium and magnesium in patients with cardiac risk factors. Correct abnormalities before continuing therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Umeclidinium-vilanterol and Vorinostat, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Umeclidinium-vilanterol
Other interactions of Vorinostat
- Thioridazine + Vorinostat Contraindicated
- Amiodarone + Vorinostat Major
- Amisulpride + Vorinostat Major
- Anagrelide + Vorinostat Major
- Asenapine + Vorinostat Major
- Chlorpromazine + Vorinostat Major
Frequently asked questions
Can I take Umeclidinium-vilanterol with Vorinostat?
MediHelp rates the interaction as moderate. Umeclidinium-vilanterol and Vorinostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vorinostat has been associated with QT changes and electrolyte disturbances, and vilanterol may add to cardiac effects. The combined risk is generally modest but relevant in at-risk patients.
How serious is the interaction between Umeclidinium-vilanterol and Vorinostat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG, potassium and magnesium in patients with cardiac risk factors. Correct abnormalities before continuing therapy.
What other medicines interact with Umeclidinium-vilanterol?
MediHelp also lists interactions of Umeclidinium-vilanterol with, for example, Aclidinium, Amiodarone, Amitriptyline. The full list is on the Umeclidinium-vilanterol page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
