Drug interactions
Upadacitinib + Voclosporin
Severity: Major
Upadacitinib and Voclosporin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voclosporin is a calcineurin inhibitor and upadacitinib a JAK inhibitor; together they produce strong immunosuppression with increased risk of serious infection and malignancy. Labeling for upadacitinib advises against use with potent immunosuppressants such as calcineurin inhibitors.
What this interaction means in plain words
Upadacitinib and Voclosporin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Upadacitinib belongs to Musculoskeletal; Voclosporin belongs to Miscellaneous.
Why it happens
Additive immunosuppression through calcineurin inhibition and JAK inhibition.
What to do
Avoid the combination; choose an alternative regimen. If unavoidable, monitor closely for infection.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Upadacitinib
- Abrocitinib + Upadacitinib Contraindicated
- Adenovirus types 4 and 7 live + Upadacitinib Contraindicated
- Baricitinib + Upadacitinib Contraindicated
- Bcg vaccine live + Upadacitinib Contraindicated
- Cyclosporine + Upadacitinib Contraindicated
- Dengue vaccine + Upadacitinib Contraindicated
Other interactions of Voclosporin
- Clarithromycin + Voclosporin Contraindicated
- Cyclosporin + Voclosporin Contraindicated
- Ensitrelvir + Voclosporin Contraindicated
- Itraconazole + Voclosporin Contraindicated
- Ketoconazole + Voclosporin Contraindicated
- Posaconazole + Voclosporin Contraindicated
Frequently asked questions
Can I take Upadacitinib with Voclosporin?
MediHelp rates the interaction as major. Upadacitinib and Voclosporin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Voclosporin is a calcineurin inhibitor and upadacitinib a JAK inhibitor; together they produce strong immunosuppression with increased risk of serious infection and malignancy. Labeling for upadacitinib advises against use with potent immunosuppressants such as calcineurin inhibitors.
How serious is the interaction between Upadacitinib and Voclosporin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; choose an alternative regimen. If unavoidable, monitor closely for infection.
What other medicines interact with Upadacitinib?
MediHelp also lists interactions of Upadacitinib with, for example, Abrocitinib, Adenovirus types 4 and 7 live, Baricitinib. The full list is on the Upadacitinib page.
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