Drug interactions
Vadadustat + Valsartan
Severity: Moderate
Vadadustat and Valsartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Valsartan may raise vadadustat exposure, which could cause a larger or faster hemoglobin rise than intended. This increases the risk of thromboembolic and other adverse effects of vadadustat.
What this interaction means in plain words
Vadadustat and Valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Vadadustat belongs to Endocrine; Valsartan belongs to Cardiovascular.
Why it happens
Valsartan may inhibit OAT1/OAT3 transporters involved in vadadustat renal elimination, increasing its plasma concentration.
What to do
Monitor hemoglobin regularly after starting or changing valsartan and reduce or interrupt the vadadustat dose per labeling if the rise is too rapid.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Valsartan
- Aliskiren + Valsartan Contraindicated
- Sparsentan + Valsartan Contraindicated
- Aldesleukin + Valsartan Major
- Amifostine + Valsartan Major
- Amiloride + Valsartan Major
- Amlodipine-benazepril + Valsartan Major
Other interactions of Vadadustat
- Atorvastatin + Vadadustat Moderate
- Balsalazide + Vadadustat Moderate
- Baricitinib + Vadadustat Moderate
- Benzathine penicillin g + Vadadustat Moderate
- Calcium carbonate + Vadadustat Moderate
- Calcium + Vadadustat Moderate
Frequently asked questions
Can I take Vadadustat with Valsartan?
MediHelp rates the interaction as moderate. Vadadustat and Valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Valsartan may raise vadadustat exposure, which could cause a larger or faster hemoglobin rise than intended. This increases the risk of thromboembolic and other adverse effects of vadadustat.
How serious is the interaction between Vadadustat and Valsartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor hemoglobin regularly after starting or changing valsartan and reduce or interrupt the vadadustat dose per labeling if the rise is too rapid.
What other medicines interact with Valsartan?
MediHelp also lists interactions of Valsartan with, for example, Aliskiren, Sparsentan, Aldesleukin. The full list is on the Valsartan page.
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