Drug interactions
Vardenafil + Vemurafenib
Severity: Moderate
Vardenafil and Vemurafenib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vemurafenib causes concentration-dependent QT prolongation, and vardenafil adds a small effect. The combination may increase the risk of torsades de pointes.
What this interaction means in plain words
Vardenafil and Vemurafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Vardenafil belongs to Genitourinary; Vemurafenib belongs to Oncology.
Why it happens
Additive QT prolongation; vemurafenib is also a CYP3A4 inducer that may reduce vardenafil exposure.
What to do
Monitor ECG and electrolytes if the combination is needed. Consider an alternative ED therapy in patients with QTc prolongation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vardenafil
- Amyl nitrite + Vardenafil Contraindicated
- Glyceryl trinitrate pr + Vardenafil Contraindicated
- Isosorbide dinitrate + Vardenafil Contraindicated
- Isosorbide mononitrate + Vardenafil Contraindicated
- Nicorandil + Vardenafil Contraindicated
- Nitroglycerin po + Vardenafil Contraindicated
Other interactions of Vemurafenib
Frequently asked questions
Can I take Vardenafil with Vemurafenib?
MediHelp rates the interaction as moderate. Vardenafil and Vemurafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vemurafenib causes concentration-dependent QT prolongation, and vardenafil adds a small effect. The combination may increase the risk of torsades de pointes.
How serious is the interaction between Vardenafil and Vemurafenib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and electrolytes if the combination is needed. Consider an alternative ED therapy in patients with QTc prolongation.
What other medicines interact with Vardenafil?
MediHelp also lists interactions of Vardenafil with, for example, Amyl nitrite, Glyceryl trinitrate pr, Isosorbide dinitrate. The full list is on the Vardenafil page.
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