Drug interactions
Vemurafenib + Vinblastine
Severity: Moderate
Vemurafenib and Vinblastine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vemurafenib inhibits P-glycoprotein in vitro and could raise vinblastine exposure. This may increase myelosuppression and neurotoxicity.
What this interaction means in plain words
Vemurafenib and Vinblastine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Vemurafenib belongs to Oncology; Vinblastine belongs to Oncology.
Why it happens
Vemurafenib inhibits P-glycoprotein-mediated efflux of vinblastine.
What to do
Monitor blood counts and neurotoxicity, and reduce the vinblastine dose if toxicity appears.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vinblastine
Other interactions of Vemurafenib
Frequently asked questions
Can I take Vemurafenib with Vinblastine?
MediHelp rates the interaction as moderate. Vemurafenib and Vinblastine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vemurafenib inhibits P-glycoprotein in vitro and could raise vinblastine exposure. This may increase myelosuppression and neurotoxicity.
How serious is the interaction between Vemurafenib and Vinblastine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and neurotoxicity, and reduce the vinblastine dose if toxicity appears.
What other medicines interact with Vinblastine?
MediHelp also lists interactions of Vinblastine with, for example, Adenovirus types 4 and 7 live, Apalutamide, Atazanavir. The full list is on the Vinblastine page.
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