Drug interactions
Vinblastine + Voriconazole
Severity: Major
Vinblastine and Voriconazole: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vinblastine is a CYP3A4 substrate, and azole inhibition can increase its exposure. This may lead to enhanced myelosuppression and neurotoxicity.
What this interaction means in plain words
Vinblastine and Voriconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Vinblastine belongs to Oncology; Voriconazole belongs to Anti Fungals.
Why it happens
Voriconazole inhibits CYP3A4 metabolism of vinblastine and may affect P-glycoprotein.
What to do
Prefer a non-interacting antifungal if possible. Otherwise monitor blood counts and neurotoxicity closely and consider vinblastine dose reduction.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Vinblastine and Voriconazole, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Other interactions of Vinblastine
Frequently asked questions
Can I take Vinblastine with Voriconazole?
MediHelp rates the interaction as major. Vinblastine and Voriconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Vinblastine is a CYP3A4 substrate, and azole inhibition can increase its exposure. This may lead to enhanced myelosuppression and neurotoxicity.
How serious is the interaction between Vinblastine and Voriconazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer a non-interacting antifungal if possible. Otherwise monitor blood counts and neurotoxicity closely and consider vinblastine dose reduction.
What other medicines interact with Voriconazole?
MediHelp also lists interactions of Voriconazole with, for example, Avanafil, Butabarbital, Carbamazepine. The full list is on the Voriconazole page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
