Drug interactions
Voriconazole + Zafirlukast
Severity: Minor
Voriconazole and Zafirlukast: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Zafirlukast inhibits CYP2C9 in vitro, and voriconazole is partly cleared by CYP2C9, so voriconazole exposure could rise slightly. No meaningful clinical effect has been shown, and the interaction is largely theoretical.
What this interaction means in plain words
Voriconazole and Zafirlukast have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Voriconazole belongs to Anti Fungals; Zafirlukast belongs to Respiratory.
Why it happens
Possible inhibition of CYP2C9-mediated voriconazole metabolism by zafirlukast, predicted from in vitro data.
What to do
No routine adjustment is needed. Watch for voriconazole adverse effects such as visual disturbance or liver enzyme elevation if both drugs are used together.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Zafirlukast
- Pimozide + Zafirlukast Contraindicated
- Lomitapide + Zafirlukast Major
- Nilotinib + Zafirlukast Major
- Warfarin + Zafirlukast Major
- Apalutamide + Zafirlukast Moderate
- Carbamazepine + Zafirlukast Moderate
Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Frequently asked questions
Can I take Voriconazole with Zafirlukast?
MediHelp rates the interaction as minor. Voriconazole and Zafirlukast have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Zafirlukast inhibits CYP2C9 in vitro, and voriconazole is partly cleared by CYP2C9, so voriconazole exposure could rise slightly. No meaningful clinical effect has been shown, and the interaction is largely theoretical.
How serious is the interaction between Voriconazole and Zafirlukast?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed. Watch for voriconazole adverse effects such as visual disturbance or liver enzyme elevation if both drugs are used together.
What other medicines interact with Zafirlukast?
MediHelp also lists interactions of Zafirlukast with, for example, Pimozide, Lomitapide, Nilotinib. The full list is on the Zafirlukast page.
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