Drug interactions
Vortioxetine + Zuranolone
Severity: Moderate
Vortioxetine and Zuranolone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Zuranolone causes somnolence and psychomotor impairment, and other CNS-active drugs may add to this effect. Combining it with an antidepressant may increase drowsiness and impair driving ability.
What this interaction means in plain words
Vortioxetine and Zuranolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Vortioxetine belongs to Central Nervous System; Zuranolone belongs to Central Nervous System.
Why it happens
Additive CNS depression; zuranolone is a positive GABA-A receptor modulator.
What to do
Monitor for excessive sedation and consider reducing the zuranolone dose if sedation occurs. Advise patients not to drive for at least 12 hours after each dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vortioxetine
- Isocarboxazid + Vortioxetine Contraindicated
- Linezolid + Vortioxetine Contraindicated
- Methylene blue + Vortioxetine Contraindicated
- Phenelzine + Vortioxetine Contraindicated
- Rasagiline + Vortioxetine Contraindicated
- Selegiline transdermal + Vortioxetine Contraindicated
Other interactions of Zuranolone
- Alprazolam + Zuranolone Major
- Amobarbital + Zuranolone Major
- Apalutamide + Zuranolone Major
- Asenapine + Zuranolone Major
- Brexpiprazole + Zuranolone Major
- Butorphanol + Zuranolone Major
Frequently asked questions
Can I take Vortioxetine with Zuranolone?
MediHelp rates the interaction as moderate. Vortioxetine and Zuranolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Zuranolone causes somnolence and psychomotor impairment, and other CNS-active drugs may add to this effect. Combining it with an antidepressant may increase drowsiness and impair driving ability.
How serious is the interaction between Vortioxetine and Zuranolone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation and consider reducing the zuranolone dose if sedation occurs. Advise patients not to drive for at least 12 hours after each dose.
What other medicines interact with Vortioxetine?
MediHelp also lists interactions of Vortioxetine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Vortioxetine page.
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