Drug interactions
Ziconotide + Ziprasidone
Severity: Moderate
Ziconotide and Ziprasidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ziconotide given intrathecally commonly causes dizziness, confusion and sedation, and serious psychiatric and cognitive adverse effects can occur. Adding a sedating antipsychotic such as ziprasidone may worsen drowsiness and cognitive impairment.
What this interaction means in plain words
Ziconotide and Ziprasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ziconotide belongs to Central Nervous System; Ziprasidone belongs to Central Nervous System.
Why it happens
Additive central nervous system depressant effects.
What to do
Monitor sedation, cognition and mood, especially after dose changes. Reduce the dose of one agent or stop ziconotide if significant cognitive or psychiatric symptoms develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ziprasidone
- Amiodarone + Ziprasidone Contraindicated
- Amitriptyline + Ziprasidone Contraindicated
- Arsenic trioxide + Ziprasidone Contraindicated
- Bedaquiline + Ziprasidone Contraindicated
- Chloroquine + Ziprasidone Contraindicated
- Citalopram + Ziprasidone Contraindicated
Other interactions of Ziconotide
- Clozapine + Ziconotide Major
- Alprazolam + Ziconotide Moderate
- Amitriptyline + Ziconotide Moderate
- Amobarbital + Ziconotide Moderate
- Aripiprazole + Ziconotide Moderate
- Armodafinil + Ziconotide Moderate
Frequently asked questions
Can I take Ziconotide with Ziprasidone?
MediHelp rates the interaction as moderate. Ziconotide and Ziprasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ziconotide given intrathecally commonly causes dizziness, confusion and sedation, and serious psychiatric and cognitive adverse effects can occur. Adding a sedating antipsychotic such as ziprasidone may worsen drowsiness and cognitive impairment.
How serious is the interaction between Ziconotide and Ziprasidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation, cognition and mood, especially after dose changes. Reduce the dose of one agent or stop ziconotide if significant cognitive or psychiatric symptoms develop.
What other medicines interact with Ziprasidone?
MediHelp also lists interactions of Ziprasidone with, for example, Amiodarone, Amitriptyline, Arsenic trioxide. The full list is on the Ziprasidone page.
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