Drug interactions
Ziprasidone + Zolmitriptan
Severity: Moderate
Ziprasidone and Zolmitriptan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs act on serotonergic systems, so there is a theoretical risk of serotonin syndrome when combined. Reports with this pairing are rare and the risk is considered low.
What this interaction means in plain words
Ziprasidone and Zolmitriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ziprasidone belongs to Central Nervous System; Zolmitriptan belongs to Central Nervous System.
Why it happens
Possible additive serotonergic activity; largely theoretical.
What to do
Advise patients to report agitation, tremor, fever, sweating or diarrhea, and stop the triptan if serotonin toxicity is suspected.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ziprasidone
- Amiodarone + Ziprasidone Contraindicated
- Amitriptyline + Ziprasidone Contraindicated
- Arsenic trioxide + Ziprasidone Contraindicated
- Bedaquiline + Ziprasidone Contraindicated
- Chloroquine + Ziprasidone Contraindicated
- Citalopram + Ziprasidone Contraindicated
Other interactions of Zolmitriptan
- Almotriptan + Zolmitriptan Contraindicated
- Dihydroergotamine intranasal + Zolmitriptan Contraindicated
- Dihydroergotamine + Zolmitriptan Contraindicated
- Eletriptan + Zolmitriptan Contraindicated
- Ergoloid mesylates + Zolmitriptan Contraindicated
- Ergotamine + Zolmitriptan Contraindicated
Frequently asked questions
Can I take Ziprasidone with Zolmitriptan?
MediHelp rates the interaction as moderate. Ziprasidone and Zolmitriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs act on serotonergic systems, so there is a theoretical risk of serotonin syndrome when combined. Reports with this pairing are rare and the risk is considered low.
How serious is the interaction between Ziprasidone and Zolmitriptan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to report agitation, tremor, fever, sweating or diarrhea, and stop the triptan if serotonin toxicity is suspected.
What other medicines interact with Ziprasidone?
MediHelp also lists interactions of Ziprasidone with, for example, Amiodarone, Amitriptyline, Arsenic trioxide. The full list is on the Ziprasidone page.
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