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Interactions médicamenteuses

Deutetrabenazine + Valbenazine

Gravité: Contre-indiquée

Deutetrabenazine and Valbenazine: contraindicated interaction.

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Résumé

Both drugs are VMAT2 inhibitors, so combining them provides duplicate therapy and increases the risk of adverse effects such as sedation, depression, parkinsonism and QT prolongation. There is no rationale for using the two together.

Ce que signifie cette interaction, en termes simples

Deutetrabenazine and Valbenazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Deutetrabenazine belongs to Central Nervous System; Valbenazine belongs to Central Nervous System.

Niveau de preuve: Moderate

Pourquoi elle survient

Duplicate VMAT2 inhibition causes additive pharmacodynamic effects and excessive monoamine depletion.

Conduite à tenir

Do not use together; choose one VMAT2 inhibitor. Allow adequate washout when switching between agents.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Deutetrabenazine with Valbenazine?

MediHelp rates the interaction as contraindicated. Deutetrabenazine and Valbenazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Both drugs are VMAT2 inhibitors, so combining them provides duplicate therapy and increases the risk of adverse effects such as sedation, depression, parkinsonism and QT prolongation. There is no rationale for using the two together.

How serious is the interaction between Deutetrabenazine and Valbenazine?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together; choose one VMAT2 inhibitor. Allow adequate washout when switching between agents.

What other medicines interact with Deutetrabenazine?

MediHelp also lists interactions of Deutetrabenazine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Deutetrabenazine page.

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