Référentiel des médicaments
Tislelizumab
Tislelizumab is a medicine in the class oncology. It is used for gastric cancer.
- Classe médicamenteuse: Oncology
- Indications: gastric cancer
Dernière mise à jour Sources: EMA SmPC
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L'essentiel
- Classe médicamenteuse
- Oncology
- Code ATC
- L01FF09
- Formes courantes
- injection
- Dosages courants
- 10 mg/ml
- Interactions connues
- 6 (Modérée: 5 · Mineure: 1)
- Noms commerciaux
- 2
- Pays et marchés
- 2
Indications
Mécanisme d'action
Humanised IgG4 variant monoclonal antibody against PD-1 that binds the extracellular domain of human PD-1 and competitively blocks binding of PD-L1 and PD-L2. This inhibits PD-1-mediated negative signalling and enhances T-cell functional activity in in vitro assays.
Posologie adulte habituelle (résumé de la notice)
Monotherapy: 200 mg once every 3 weeks or 400 mg once every 6 weeks, intravenous infusion; treat until disease progression or unacceptable toxicity
Grossesse et allaitement
- Grossesse
- Unsafe No data in pregnant women; can cause foetal harm based on its mechanism of action. Do not use during pregnancy unless the woman's clinical condition requires treatment.
- Allaitement
- Unsafe Unknown whether excreted in human milk; women should not breast-feed during treatment and for at least 4 months after the last dose.
Effets indésirables signalés
- Anaemia
- Aspartate aminotransferase increased
- Fatigue
- Alanine aminotransferase increased
- Neutropenia (with chemotherapy)
- Thrombocytopenia (with chemotherapy)
Contre-indications
- Hypersensitivity to the active substance or to any excipient.
Précautions particulières
- Immune-related adverse reactions, including fatal cases, can affect any organ system and may occur after the last dose; evaluate and withhold, with corticosteroids as needed.
- Immune-related pneumonitis, including fatal cases; monitor for signs and symptoms.
- Immune-related hepatitis; perform liver function tests at baseline and periodically.
Informez votre pharmacien ou votre médecin en cas de grossesse ou d'allaitement, de maladie rénale ou hépatique, d'allergies, ainsi que de tout autre médicament ou complément que vous prenez.
Principales interactions (6)
- Amoxicillin + Tislelizumab Moderate
- Amoxicillin-clavulanic acid + Tislelizumab Moderate
- Piperacillin + Tislelizumab Moderate
- Piperacillin-tazobactam + Tislelizumab Moderate
- Prednisone + Tislelizumab Moderate
- Penicillin g + Tislelizumab Minor
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- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- Dosing in older adults
- How to give it
- Pharmacokinetics
- Patient counselling points
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Questions fréquentes
What is Tislelizumab used for?
Tislelizumab is a medicine in the class oncology. It is used for Gastric cancer, Lung cancer, Non-small cell lung cancer.
What side effects have been reported with Tislelizumab?
Anaemia, Aspartate aminotransferase increased, Fatigue, Alanine aminotransferase increased, Neutropenia (with chemotherapy), Thrombocytopenia (with chemotherapy).
Can Tislelizumab be taken in pregnancy or while breastfeeding?
Pregnancy: Unsafe. No data in pregnant women; can cause foetal harm based on its mechanism of action. Do not use during pregnancy unless the woman's clinical condition requires treatment. Breastfeeding: Unsafe. Unknown whether excreted in human milk; women should not breast-feed during treatment and for at least 4 months after the last dose.
What does Tislelizumab interact with?
MediHelp lists 6 known interactions for Tislelizumab. Moderate: 5 · Minor: 1. The most serious include Amoxicillin, Amoxicillin-clavulanic acid, Piperacillin.
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