Interactions médicamenteuses
Prednisone + Tislelizumab
Gravité: Modérée
Prednisone and Tislelizumab: moderate interaction.
Dernière mise à jour
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Résumé
Systemic corticosteroids at higher doses before starting tislelizumab may blunt the immune response needed for its antitumor effect. Corticosteroids remain appropriate for treating immune-related adverse reactions after treatment begins.
Ce que signifie cette interaction, en termes simples
Prednisone and Tislelizumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Prednisone belongs to Endocrine; Tislelizumab belongs to Oncology.
Pourquoi elle survient
Corticosteroid immunosuppression may counteract T-cell activation produced by PD-1 blockade.
Conduite à tenir
Avoid baseline systemic prednisone above about 10 mg daily before starting tislelizumab where possible. Use corticosteroids as needed to treat immune-related adverse reactions.
Questions à poser à votre pharmacien
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Autres interactions de Tislelizumab
- Amoxicillin-clavulanic acid + Tislelizumab Modérée
- Amoxicillin + Tislelizumab Modérée
- Piperacillin-tazobactam + Tislelizumab Modérée
- Piperacillin + Tislelizumab Modérée
- Penicillin g + Tislelizumab Mineure
Autres interactions de Prednisone
- Bcg vaccine live + Prednisone Contre-indiquée
- Measles vaccine + Prednisone Contre-indiquée
- Mifepristone + Prednisone Contre-indiquée
- Prednisone + Radium-223 dichloride Contre-indiquée
- Prednisone + Smallpox vaccine live Contre-indiquée
- Adenovirus types 4 and 7 live + Prednisone Majeure
Questions fréquentes
Can I take Prednisone with Tislelizumab?
MediHelp rates the interaction as moderate. Prednisone and Tislelizumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Systemic corticosteroids at higher doses before starting tislelizumab may blunt the immune response needed for its antitumor effect. Corticosteroids remain appropriate for treating immune-related adverse reactions after treatment begins.
How serious is the interaction between Prednisone and Tislelizumab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid baseline systemic prednisone above about 10 mg daily before starting tislelizumab where possible. Use corticosteroids as needed to treat immune-related adverse reactions.
What other medicines interact with Tislelizumab?
MediHelp also lists interactions of Tislelizumab with, for example, Amoxicillin-clavulanic acid, Amoxicillin, Piperacillin-tazobactam. The full list is on the Tislelizumab page.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
