Interactions médicamenteuses
Baricitinib + Vedolizumab
Gravité: Majeure
Baricitinib and Vedolizumab: major interaction.
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Résumé
Baricitinib is a JAK inhibitor with broad immunosuppressive effects, and labeling advises against combining it with biologic DMARDs. Adding vedolizumab may increase the risk of serious infection.
Ce que signifie cette interaction, en termes simples
Baricitinib and Vedolizumab can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Baricitinib belongs to Musculoskeletal; Vedolizumab belongs to Gastrointestinal Tract.
Pourquoi elle survient
Additive immunosuppression via JAK inhibition and gut-selective integrin blockade.
Conduite à tenir
Avoid the combination and use one agent. If overlap occurs, monitor for infection.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Autres interactions de Vedolizumab
- Natalizumab + Vedolizumab Contre-indiquée
- Certolizumab pegol + Vedolizumab Majeure
- Etanercept + Vedolizumab Majeure
- Golimumab + Vedolizumab Majeure
- Smallpox vaccine live + Vedolizumab Majeure
- Upadacitinib + Vedolizumab Majeure
Autres interactions de Baricitinib
- Adenovirus types 4 and 7 live + Baricitinib Contre-indiquée
- Baricitinib + Bcg vaccine live Contre-indiquée
- Baricitinib + Tofacitinib Contre-indiquée
- Baricitinib + Upadacitinib Contre-indiquée
- Abatacept + Baricitinib Majeure
- Adalimumab + Baricitinib Majeure
Questions fréquentes
Can I take Baricitinib with Vedolizumab?
MediHelp rates the interaction as major. Baricitinib and Vedolizumab can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Baricitinib is a JAK inhibitor with broad immunosuppressive effects, and labeling advises against combining it with biologic DMARDs. Adding vedolizumab may increase the risk of serious infection.
How serious is the interaction between Baricitinib and Vedolizumab?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use one agent. If overlap occurs, monitor for infection.
What other medicines interact with Vedolizumab?
MediHelp also lists interactions of Vedolizumab with, for example, Natalizumab, Certolizumab pegol, Etanercept. The full list is on the Vedolizumab page.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
