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Interactions médicamenteuses

Certolizumab pegol + Vedolizumab

Gravité: Majeure

Certolizumab pegol and Vedolizumab: major interaction.

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Résumé

Vedolizumab labeling advises against concomitant TNF blockers because of potential for more infections. Combining them has not shown clear benefit.

Ce que signifie cette interaction, en termes simples

Certolizumab pegol and Vedolizumab can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Certolizumab pegol belongs to Musculoskeletal; Vedolizumab belongs to Gastrointestinal Tract.

Niveau de preuve: Moderate

Pourquoi elle survient

Additive immunosuppression from systemic TNF-alpha blockade and gut-selective alpha4beta7 integrin inhibition.

Conduite à tenir

Avoid concomitant use; transition between agents rather than overlap. Monitor for infection if overlap occurs.

Questions à poser à votre pharmacien

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Certolizumab pegol with Vedolizumab?

MediHelp rates the interaction as major. Certolizumab pegol and Vedolizumab can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Vedolizumab labeling advises against concomitant TNF blockers because of potential for more infections. Combining them has not shown clear benefit.

How serious is the interaction between Certolizumab pegol and Vedolizumab?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concomitant use; transition between agents rather than overlap. Monitor for infection if overlap occurs.

What other medicines interact with Certolizumab pegol?

MediHelp also lists interactions of Certolizumab pegol with, for example, Adenovirus types 4 and 7 live, Bcg intravesical live, Bcg vaccine live. The full list is on the Certolizumab pegol page.

Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp

Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

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