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Interactions médicamenteuses

Upadacitinib + Vedolizumab

Gravité: Majeure

Upadacitinib and Vedolizumab: major interaction.

Dernière mise à jour

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Résumé

Using a JAK inhibitor with another biologic immunosuppressant increases the risk of serious infection. Vedolizumab acts mainly in the gut, so systemic effects are smaller, but combination data are limited.

Ce que signifie cette interaction, en termes simples

Upadacitinib and Vedolizumab can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Upadacitinib belongs to Musculoskeletal; Vedolizumab belongs to Gastrointestinal Tract.

Niveau de preuve: Low

Pourquoi elle survient

Additive immunosuppression via gut-selective integrin blockade and JAK inhibition.

Conduite à tenir

Avoid routine concurrent use; the upadacitinib label advises against combination with biologic immunosuppressants. If combined, monitor closely for infection.

Questions à poser à votre pharmacien

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Upadacitinib with Vedolizumab?

MediHelp rates the interaction as major. Upadacitinib and Vedolizumab can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Using a JAK inhibitor with another biologic immunosuppressant increases the risk of serious infection. Vedolizumab acts mainly in the gut, so systemic effects are smaller, but combination data are limited.

How serious is the interaction between Upadacitinib and Vedolizumab?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid routine concurrent use; the upadacitinib label advises against combination with biologic immunosuppressants. If combined, monitor closely for infection.

What other medicines interact with Vedolizumab?

MediHelp also lists interactions of Vedolizumab with, for example, Natalizumab, Baricitinib, Certolizumab pegol. The full list is on the Vedolizumab page.

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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

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