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Interactions médicamenteuses

Golimumab + Vedolizumab

Gravité: Majeure

Golimumab and Vedolizumab: major interaction.

Dernière mise à jour Sources: UK SmPC

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Résumé

Vedolizumab blocks gut-selective integrin-mediated lymphocyte trafficking and golimumab blocks systemic TNF-alpha. Labeling for vedolizumab advises against use with TNF blockers because of a possible increase in infection risk.

Ce que signifie cette interaction, en termes simples

Golimumab and Vedolizumab can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Golimumab belongs to Musculoskeletal; Vedolizumab belongs to Gastrointestinal Tract.

Niveau de preuve: Moderate

Pourquoi elle survient

Additive immunosuppression via gut-selective integrin blockade and TNF-alpha inhibition.

Conduite à tenir

Avoid combination use. Transition from one agent to the other with a planned switch and monitor for infection.

Questions à poser à votre pharmacien

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Références

Questions fréquentes

Can I take Golimumab with Vedolizumab?

MediHelp rates the interaction as major. Golimumab and Vedolizumab can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Vedolizumab blocks gut-selective integrin-mediated lymphocyte trafficking and golimumab blocks systemic TNF-alpha. Labeling for vedolizumab advises against use with TNF blockers because of a possible increase in infection risk.

How serious is the interaction between Golimumab and Vedolizumab?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combination use. Transition from one agent to the other with a planned switch and monitor for infection.

What other medicines interact with Golimumab?

MediHelp also lists interactions of Golimumab with, for example, Bcg vaccine live, Etanercept, Influenza virus vaccine quadrivalent intranasal. The full list is on the Golimumab page.

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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

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