Interactions médicamenteuses
Blinatumomab + Theophylline
Gravité: Modérée
Blinatumomab and Theophylline: moderate interaction.
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Résumé
Blinatumomab causes a transient cytokine release at treatment start that can suppress CYP450 enzymes. Theophylline, a narrow therapeutic index CYP1A2 substrate, may accumulate and cause toxicity such as tachyarrhythmia, nausea or seizures.
Ce que signifie cette interaction, en termes simples
Blinatumomab and Theophylline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Blinatumomab belongs to Oncology; Theophylline belongs to Respiratory.
Pourquoi elle survient
Cytokine-mediated transient suppression of hepatic CYP450 enzymes (including CYP1A2) reduces theophylline clearance.
Conduite à tenir
Monitor theophylline serum levels and signs of toxicity during the first days of the first cycle and when restarting after an interruption. Reduce the theophylline dose if levels rise.
Questions à poser à votre pharmacien
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Autres interactions de Theophylline
- Riociguat + Theophylline Contre-indiquée
- Adenosine + Theophylline Majeure
- Apalutamide + Theophylline Majeure
- Bupropion + Theophylline Majeure
- Carvedilol + Theophylline Majeure
- Cimetidine + Theophylline Majeure
Autres interactions de Blinatumomab
- Blinatumomab + Carbamazepine Modérée
- Blinatumomab + Cyclosporin Modérée
- Blinatumomab + Ethosuximide Modérée
- Blinatumomab + Phenytoin Modérée
- Blinatumomab + Quinidine Modérée
- Blinatumomab + Quinine Modérée
Questions fréquentes
Can I take Blinatumomab with Theophylline?
MediHelp rates the interaction as moderate. Blinatumomab and Theophylline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Blinatumomab causes a transient cytokine release at treatment start that can suppress CYP450 enzymes. Theophylline, a narrow therapeutic index CYP1A2 substrate, may accumulate and cause toxicity such as tachyarrhythmia, nausea or seizures.
How serious is the interaction between Blinatumomab and Theophylline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor theophylline serum levels and signs of toxicity during the first days of the first cycle and when restarting after an interruption. Reduce the theophylline dose if levels rise.
What other medicines interact with Theophylline?
MediHelp also lists interactions of Theophylline with, for example, Riociguat, Adenosine, Apalutamide. The full list is on the Theophylline page.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
