Interactions médicamenteuses
Cimetidine + Dasatinib
Gravité: Majeure
Cimetidine and Dasatinib: major interaction.
Dernière mise à jour
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Résumé
Cimetidine can raise dasatinib exposure through CYP3A4 inhibition, but as an H2 blocker it also lowers gastric acidity, which reduces dasatinib absorption because its solubility depends on acid. The net effect is unpredictable and may result in either toxicity or reduced efficacy.
Ce que signifie cette interaction, en termes simples
Cimetidine and Dasatinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Cimetidine belongs to Gastrointestinal Tract; Dasatinib belongs to Oncology.
Pourquoi elle survient
Weak CYP3A4 inhibition by cimetidine may increase dasatinib levels, while the rise in gastric pH decreases dasatinib dissolution and absorption.
Conduite à tenir
Avoid H2 blockers with dasatinib; use an antacid given at least 2 hours before or after dasatinib if acid suppression is needed. Monitor response and toxicity if combination cannot be avoided.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Autres interactions de Cimetidine
- Cimetidine + Dofetilide Contre-indiquée
- Cimetidine + Fezolinetant Contre-indiquée
- Alfentanil + Cimetidine Majeure
- Atazanavir + Cimetidine Majeure
- Carmustine + Cimetidine Majeure
- Cimetidine + Citalopram Majeure
Autres interactions de Dasatinib
- Dasatinib + Saquinavir Contre-indiquée
- Dasatinib + Thioridazine Contre-indiquée
- Adagrasib + Dasatinib Majeure
- Amiodarone + Dasatinib Majeure
- Amisulpride + Dasatinib Majeure
- Amitriptyline + Dasatinib Majeure
Questions fréquentes
Can I take Cimetidine with Dasatinib?
MediHelp rates the interaction as major. Cimetidine and Dasatinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Cimetidine can raise dasatinib exposure through CYP3A4 inhibition, but as an H2 blocker it also lowers gastric acidity, which reduces dasatinib absorption because its solubility depends on acid. The net effect is unpredictable and may result in either toxicity or reduced efficacy.
How serious is the interaction between Cimetidine and Dasatinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid H2 blockers with dasatinib; use an antacid given at least 2 hours before or after dasatinib if acid suppression is needed. Monitor response and toxicity if combination cannot be avoided.
What other medicines interact with Cimetidine?
MediHelp also lists interactions of Cimetidine with, for example, Dofetilide, Fezolinetant, Alfentanil. The full list is on the Cimetidine page.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
