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Interactions médicamenteuses

Clomipramine + Liothyronine

Gravité: Modérée

Clomipramine and Liothyronine: moderate interaction.

Dernière mise à jour

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Résumé

Thyroid hormones can increase sensitivity to catecholamines and tricyclics may enhance this effect. The combination can raise the risk of tachyarrhythmias and CNS stimulation, particularly with excess thyroid hormone. Tricyclic effect may also be accelerated when thyroid hormone is used for augmentation.

Ce que signifie cette interaction, en termes simples

Clomipramine and Liothyronine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.

Clomipramine belongs to Central Nervous System; Liothyronine belongs to Endocrine.

Niveau de preuve: Moderate

Pourquoi elle survient

Thyroid hormone increases adrenergic receptor sensitivity, adding to tricyclic noradrenergic and cardiac effects.

Conduite à tenir

Monitor heart rate, rhythm and thyroid function, and watch for agitation or tremor. Keep thyroid replacement dose at the lowest effective level.

Questions à poser à votre pharmacien

  • Should I take them at different times of day?
  • Does the dose of either medicine need to change?
  • Is there anything I should avoid, such as alcohol or certain foods, while on both?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Clomipramine with Liothyronine?

MediHelp rates the interaction as moderate. Clomipramine and Liothyronine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thyroid hormones can increase sensitivity to catecholamines and tricyclics may enhance this effect. The combination can raise the risk of tachyarrhythmias and CNS stimulation, particularly with excess thyroid hormone. Tricyclic effect may also be accelerated when thyroid hormone is used for augmentation.

How serious is the interaction between Clomipramine and Liothyronine?

MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, rhythm and thyroid function, and watch for agitation or tremor. Keep thyroid replacement dose at the lowest effective level.

What other medicines interact with Clomipramine?

MediHelp also lists interactions of Clomipramine with, for example, Arsenic trioxide, Dofetilide, Droperidol. The full list is on the Clomipramine page.

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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

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