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Interactions médicamenteuses

Cocaine + Duloxetine

Gravité: Majeure

Cocaine and Duloxetine: major interaction.

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Résumé

Cocaine blocks reuptake of serotonin, norepinephrine and dopamine, so systemic cocaine use with duloxetine may increase serotonin toxicity and cardiovascular stimulation. Topical medical cocaine has little systemic absorption, so the risk is mostly with illicit or high-dose use.

Ce que signifie cette interaction, en termes simples

Cocaine and Duloxetine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Cocaine belongs to Central Nervous System; Duloxetine belongs to Central Nervous System.

Niveau de preuve: Low

Pourquoi elle survient

Additive monoamine reuptake inhibition causing serotonergic and sympathomimetic effects.

Conduite à tenir

Counsel patients to avoid cocaine use and monitor for serotonin syndrome, hypertension and tachycardia if exposure occurs. For topical use, limit dose to the minimum needed.

Questions à poser à votre pharmacien

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Cocaine with Duloxetine?

MediHelp rates the interaction as major. Cocaine and Duloxetine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Cocaine blocks reuptake of serotonin, norepinephrine and dopamine, so systemic cocaine use with duloxetine may increase serotonin toxicity and cardiovascular stimulation. Topical medical cocaine has little systemic absorption, so the risk is mostly with illicit or high-dose use.

How serious is the interaction between Cocaine and Duloxetine?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients to avoid cocaine use and monitor for serotonin syndrome, hypertension and tachycardia if exposure occurs. For topical use, limit dose to the minimum needed.

What other medicines interact with Duloxetine?

MediHelp also lists interactions of Duloxetine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Duloxetine page.

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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

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