Interactions médicamenteuses
Cyclobenzaprine + Isocarboxazid
Gravité: Contre-indiquée
Cyclobenzaprine and Isocarboxazid: contraindicated interaction.
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Résumé
Isocarboxazid inhibits monoamine oxidase and so reduces serotonin breakdown, while cyclobenzaprine is a tricyclic-related muscle relaxant that inhibits serotonin and norepinephrine reuptake. Together this can precipitate serotonin syndrome, with agitation, hyperthermia, clonus and autonomic instability that may be fatal. Hypertensive reactions are also possible with tricyclic agents.
Ce que signifie cette interaction, en termes simples
Cyclobenzaprine and Isocarboxazid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Cyclobenzaprine belongs to Musculoskeletal; Isocarboxazid belongs to Central Nervous System.
Pourquoi elle survient
Additive serotonergic activity: irreversible non-selective MAO inhibition plus monoamine reuptake inhibition
Conduite à tenir
Do not combine; allow at least 14 days after stopping the isocarboxazid before starting cyclobenzaprine, and at least 14 days after stopping cyclobenzaprine before starting the isocarboxazid.
Questions à poser à votre pharmacien
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Autres interactions de Cyclobenzaprine
- Cyclobenzaprine + Linezolid Contre-indiquée
- Cyclobenzaprine + Phenelzine Contre-indiquée
- Cyclobenzaprine + Safinamide Contre-indiquée
- Cyclobenzaprine + Selegiline Contre-indiquée
- Cyclobenzaprine + Selegiline transdermal Contre-indiquée
- Cyclobenzaprine + Tranylcypromine Contre-indiquée
Autres interactions de Isocarboxazid
- 5-HTP + Isocarboxazid Contre-indiquée
- Amitriptyline + Isocarboxazid Contre-indiquée
- Amobarbital + Isocarboxazid Contre-indiquée
- Amoxapine + Isocarboxazid Contre-indiquée
- Apraclonidine + Isocarboxazid Contre-indiquée
- Atomoxetine + Isocarboxazid Contre-indiquée
Questions fréquentes
Can I take Cyclobenzaprine with Isocarboxazid?
MediHelp rates the interaction as contraindicated. Cyclobenzaprine and Isocarboxazid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Isocarboxazid inhibits monoamine oxidase and so reduces serotonin breakdown, while cyclobenzaprine is a tricyclic-related muscle relaxant that inhibits serotonin and norepinephrine reuptake. Together this can precipitate serotonin syndrome, with agitation, hyperthermia, clonus and autonomic instability that may be fatal. Hypertensive reactions are also possible with tricyclic agents.
How serious is the interaction between Cyclobenzaprine and Isocarboxazid?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine; allow at least 14 days after stopping the isocarboxazid before starting cyclobenzaprine, and at least 14 days after stopping cyclobenzaprine before starting the isocarboxazid.
What other medicines interact with Cyclobenzaprine?
MediHelp also lists interactions of Cyclobenzaprine with, for example, Linezolid, Phenelzine, Safinamide. The full list is on the Cyclobenzaprine page.
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