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Interactions médicamenteuses

Cyclobenzaprine + Selegiline

Gravité: Contre-indiquée

Cyclobenzaprine and Selegiline: contraindicated interaction.

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Résumé

Selegiline is an MAO-B inhibitor that becomes nonselective at higher doses, and the transdermal form is used for depression. With cyclobenzaprine, there is a risk of serotonin syndrome and hypertensive crisis. The cyclobenzaprine label contraindicates use with MAO inhibitors.

Ce que signifie cette interaction, en termes simples

Cyclobenzaprine and Selegiline are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Cyclobenzaprine belongs to Musculoskeletal; Selegiline belongs to Central Nervous System.

Niveau de preuve: Moderate

Pourquoi elle survient

MAO inhibition combined with serotonergic and noradrenergic reuptake effects of cyclobenzaprine increases monoamine levels.

Conduite à tenir

Do not combine, and avoid cyclobenzaprine within 14 days of stopping an MAO inhibitor. Use a non-serotonergic alternative for muscle spasm.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Cyclobenzaprine with Selegiline?

MediHelp rates the interaction as contraindicated. Cyclobenzaprine and Selegiline are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Selegiline is an MAO-B inhibitor that becomes nonselective at higher doses, and the transdermal form is used for depression. With cyclobenzaprine, there is a risk of serotonin syndrome and hypertensive crisis. The cyclobenzaprine label contraindicates use with MAO inhibitors.

How serious is the interaction between Cyclobenzaprine and Selegiline?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine, and avoid cyclobenzaprine within 14 days of stopping an MAO inhibitor. Use a non-serotonergic alternative for muscle spasm.

What other medicines interact with Cyclobenzaprine?

MediHelp also lists interactions of Cyclobenzaprine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Cyclobenzaprine page.

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