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Interactions médicamenteuses

Cyclosporin + Red yeast rice

Gravité: Majeure

Cyclosporin and Red yeast rice: major interaction.

Dernière mise à jour

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Résumé

Red yeast rice contains monacolin K, chemically identical to lovastatin, so cyclosporine can raise statin exposure and the risk of myopathy and rhabdomyolysis. Product content is variable and unregulated, which makes the exposure unpredictable.

Ce que signifie cette interaction, en termes simples

Cyclosporin and Red yeast rice can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Cyclosporin belongs to Miscellaneous; Red yeast rice belongs to Gastrointestinal Tract.

Niveau de preuve: Moderate

Pourquoi elle survient

Cyclosporine inhibits CYP3A4 and OATP-mediated disposition of monacolin K (lovastatin), increasing its systemic levels.

Conduite à tenir

Avoid red yeast rice in patients taking cyclosporine and use a prescribed statin with labeled dose limits if lipid lowering is needed. Report muscle pain or dark urine promptly.

Questions à poser à votre pharmacien

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Cyclosporin with Red yeast rice?

MediHelp rates the interaction as major. Cyclosporin and Red yeast rice can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Red yeast rice contains monacolin K, chemically identical to lovastatin, so cyclosporine can raise statin exposure and the risk of myopathy and rhabdomyolysis. Product content is variable and unregulated, which makes the exposure unpredictable.

How serious is the interaction between Cyclosporin and Red yeast rice?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid red yeast rice in patients taking cyclosporine and use a prescribed statin with labeled dose limits if lipid lowering is needed. Report muscle pain or dark urine promptly.

What other medicines interact with Cyclosporin?

MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.

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