Interactions médicamenteuses
Domperidone + Omeprazole
Gravité: Mineure
Domperidone and Omeprazole: minor interaction.
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Résumé
Reduced gastric acidity from omeprazole may lower the absorption of domperidone, which needs an acidic environment for dissolution. This may reduce the prokinetic or antiemetic effect. The clinical impact is usually modest, and omeprazole does not meaningfully inhibit CYP3A4 or add to QT risk.
Ce que signifie cette interaction, en termes simples
Domperidone and Omeprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Domperidone belongs to Gastrointestinal Tract; Omeprazole belongs to Gastrointestinal Tract.
Pourquoi elle survient
Higher gastric pH from proton pump inhibition reduces domperidone dissolution and absorption. It is not mediated through CYP3A4.
Conduite à tenir
Give domperidone 15 to 30 minutes before meals as labelled. Review clinical response and adjust therapy if efficacy is reduced.
Questions à poser à votre pharmacien
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Références
- Motilium (domperidone) Summary of Product Characteristics — EMA SmPC
Autres interactions de Domperidone
- Azithromycin + Domperidone Contre-indiquée
- Domperidone + Erythromycin Contre-indiquée
- Dexlansoprazole + Domperidone Modérée
- Domperidone + Lansoprazole Modérée
- Domperidone + Pantoprazole Modérée
- Domperidone + Polyethylene Glycol 3350 Modérée
Autres interactions de Omeprazole
- Mavacamten + Omeprazole Contre-indiquée
- Omeprazole + Rilpivirine Contre-indiquée
- Acalabrutinib + Omeprazole Majeure
- Atazanavir + Omeprazole Majeure
- Citalopram + Omeprazole Majeure
- Clopidogrel + Omeprazole Majeure
Questions fréquentes
Can I take Domperidone with Omeprazole?
MediHelp rates the interaction as minor. Domperidone and Omeprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Reduced gastric acidity from omeprazole may lower the absorption of domperidone, which needs an acidic environment for dissolution. This may reduce the prokinetic or antiemetic effect. The clinical impact is usually modest, and omeprazole does not meaningfully inhibit CYP3A4 or add to QT risk.
How serious is the interaction between Domperidone and Omeprazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give domperidone 15 to 30 minutes before meals as labelled. Review clinical response and adjust therapy if efficacy is reduced.
What other medicines interact with Domperidone?
MediHelp also lists interactions of Domperidone with, for example, Azithromycin, Erythromycin, Dexlansoprazole. The full list is on the Domperidone page.
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