Interactions médicamenteuses
Domperidone + Pantoprazole
Gravité: Modérée
Domperidone and Pantoprazole: moderate interaction.
Dernière mise à jour Sources: US FDA label
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Résumé
Prolonged pantoprazole use can cause hypomagnesaemia, and low magnesium or potassium increases susceptibility to QT prolongation and torsades de pointes with domperidone. This is an indirect, risk-factor-based interaction and is mainly relevant with long-term PPI use. Patients with cardiac disease, older patients and those taking diuretics are at higher risk.
Ce que signifie cette interaction, en termes simples
Domperidone and Pantoprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Domperidone belongs to Gastrointestinal Tract; Pantoprazole belongs to Gastrointestinal Tract.
Pourquoi elle survient
Pharmacodynamic: PPI-induced hypomagnesaemia, often with hypokalaemia, lowers the threshold for domperidone-related QTc prolongation.
Conduite à tenir
Use the lowest effective domperidone dose for the shortest time. Check serum magnesium and potassium, particularly if PPI therapy has lasted more than about 3 months or the patient takes diuretics or digoxin, and correct deficits.
Questions à poser à votre pharmacien
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Références
- Motilium (domperidone) Summary of Product Characteristics — EMA SmPC
- Protonix (pantoprazole) Prescribing Information - Warnings: Hypomagnesemia — FDA Label
Autres interactions de Domperidone
- Azithromycin + Domperidone Contre-indiquée
- Domperidone + Erythromycin Contre-indiquée
- Dexlansoprazole + Domperidone Modérée
- Domperidone + Lansoprazole Modérée
- Domperidone + Polyethylene Glycol 3350 Modérée
- Domperidone + Rabeprazole Modérée
Autres interactions de Pantoprazole
- Pantoprazole + Rilpivirine Contre-indiquée
- Acalabrutinib + Pantoprazole Majeure
- Atazanavir + Pantoprazole Majeure
- Dacomitinib + Pantoprazole Majeure
- Dasatinib + Pantoprazole Majeure
- Erlotinib + Pantoprazole Majeure
Questions fréquentes
Can I take Domperidone with Pantoprazole?
MediHelp rates the interaction as moderate. Domperidone and Pantoprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Prolonged pantoprazole use can cause hypomagnesaemia, and low magnesium or potassium increases susceptibility to QT prolongation and torsades de pointes with domperidone. This is an indirect, risk-factor-based interaction and is mainly relevant with long-term PPI use. Patients with cardiac disease, older patients and those taking diuretics are at higher risk.
How serious is the interaction between Domperidone and Pantoprazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective domperidone dose for the shortest time. Check serum magnesium and potassium, particularly if PPI therapy has lasted more than about 3 months or the patient takes diuretics or digoxin, and correct deficits.
What other medicines interact with Domperidone?
MediHelp also lists interactions of Domperidone with, for example, Azithromycin, Erythromycin, Dexlansoprazole. The full list is on the Domperidone page.
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