Interactions médicamenteuses
Domperidone + Erythromycin
Gravité: Contre-indiquée
Domperidone and Erythromycin: contraindicated interaction.
Dernière mise à jour Sources: US FDA label
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Résumé
Erythromycin markedly raises domperidone exposure and both drugs prolong the QT interval, increasing the risk of torsades de pointes and sudden cardiac death. Domperidone labeling in Europe contraindicates co-administration with QT-prolonging drugs and potent CYP3A4 inhibitors. Risk is greater in older patients, those with cardiac disease, electrolyte disturbances or higher domperidone doses.
Ce que signifie cette interaction, en termes simples
Domperidone and Erythromycin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Domperidone belongs to Gastrointestinal Tract; Erythromycin belongs to Anti Bacterial.
Pourquoi elle survient
Erythromycin inhibits CYP3A4, the main metabolic pathway of domperidone, and both drugs block the hERG potassium channel, giving additive QT prolongation.
Conduite à tenir
Do not combine; choose a non-QT-prolonging antiemetic or prokinetic, or a different antibiotic such as one without CYP3A4 inhibition or QT effects. If erythromycin is essential, withhold domperidone for the course.
Questions à poser à votre pharmacien
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Références
- Domperidone SmPC - Contraindications and Interactions — EMA SmPC
- Erythromycin Prescribing Information - Drug Interactions — FDA Label
Autres interactions de Domperidone
- Azithromycin + Domperidone Contre-indiquée
- Dexlansoprazole + Domperidone Modérée
- Domperidone + Lansoprazole Modérée
- Domperidone + Pantoprazole Modérée
- Domperidone + Polyethylene Glycol 3350 Modérée
- Domperidone + Rabeprazole Modérée
Autres interactions de Erythromycin
- Conivaptan + Erythromycin Contre-indiquée
- Dihydroergotamine intranasal + Erythromycin Contre-indiquée
- Dihydroergotamine + Erythromycin Contre-indiquée
- Dronedarone + Erythromycin Contre-indiquée
- Droperidol + Erythromycin Contre-indiquée
- Ergotamine + Erythromycin Contre-indiquée
Questions fréquentes
Can I take Domperidone with Erythromycin?
MediHelp rates the interaction as contraindicated. Domperidone and Erythromycin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Erythromycin markedly raises domperidone exposure and both drugs prolong the QT interval, increasing the risk of torsades de pointes and sudden cardiac death. Domperidone labeling in Europe contraindicates co-administration with QT-prolonging drugs and potent CYP3A4 inhibitors. Risk is greater in older patients, those with cardiac disease, electrolyte disturbances or higher domperidone doses.
How serious is the interaction between Domperidone and Erythromycin?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine; choose a non-QT-prolonging antiemetic or prokinetic, or a different antibiotic such as one without CYP3A4 inhibition or QT effects. If erythromycin is essential, withhold domperidone for the course.
What other medicines interact with Domperidone?
MediHelp also lists interactions of Domperidone with, for example, Azithromycin, Dexlansoprazole, Lansoprazole. The full list is on the Domperidone page.
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