Référentiel des médicaments
Domperidone
Domperidone is a medicine in the class gastrointestinal tract. It is used for dyspepsia.
- Classe médicamenteuse: Gastrointestinal Tract
- Indications: dyspepsia
Dernière mise à jour Sources: Health Canada product monograph, UK SmPC
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L'essentiel
- Classe médicamenteuse
- Gastrointestinal Tract
- Formes courantes
- comprimé, suppositoire, suspension buvable, sachet, gélule, sirop
- Dosages courants
- 10 mg, 1 mg/ml, 60 mg
- Interactions connues
- 8 (Contre-indiquée: 2 · Modérée: 5 · Mineure: 1)
- Noms commerciaux
- 69
- Pays et marchés
- 4
Indications
Mécanisme d'action
Domperidone is a dopamine antagonist with anti-emetic properties, Domperidone does not readily cross the blood-brain barrier. Domperidone promotes the release of prolactin from the pituitary.
Posologie adulte habituelle (résumé de la notice)
One 10mg tablet up to three times per day with maximum dose of 30 mg per day.
Grossesse et allaitement
- Grossesse
- Unknown Limited human data have not shown a rise in birth defects; high, maternally toxic doses harmed rat fetuses. UK label: use in pregnancy only when justified by the expected benefit. Better-studied antiemetics are preferred for pregnancy sickness.
- Allaitement
- Safe Very low milk levels (under 0.1% of the mother's dose) and no infant harm in published cases; it is used to boost milk supply. It carries a heart rhythm risk for the mother. UK label: decide between breastfeeding and the drug, as infant heart effects cannot be excluded.
Effets indésirables signalés
- Headache
- Dry mouth
- Diarrhea
- Somnolence
Contre-indications
- Hypersensitivity to domperidone or any formulation ingredient.
- Known prolongation of cardiac conduction intervals, particularly QT; significant electrolyte disturbances; underlying cardiac disease such as congestive heart failure.
- Moderate or severe liver impairment.
Précautions particulières
- May be associated with serious ventricular arrhythmias or sudden cardiac death; risk may be higher in patients over 60 or at daily doses above 30 mg. Use the lowest dose for the shortest duration.
- Patients at higher risk of QT prolongation or arrhythmia should be considered for cardiac assessment before and during treatment.
- Moderate CYP3A4 inhibitors such as diltiazem, verapamil and some macrolides are not recommended with domperidone.
Informez votre pharmacien ou votre médecin en cas de grossesse ou d'allaitement, de maladie rénale ou hépatique, d'allergies, ainsi que de tout autre médicament ou complément que vous prenez.
Principales interactions (8)
- Azithromycin + Domperidone Contraindicated
- Domperidone + Erythromycin Contraindicated
- Dexlansoprazole + Domperidone Moderate
- Domperidone + Lansoprazole Moderate
- Domperidone + Pantoprazole Moderate
- Domperidone + Polyethylene Glycol 3350 Moderate
- Domperidone + Rabeprazole Moderate
- Domperidone + Omeprazole Minor
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- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- Paediatric dosing
- Dosing in older adults
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- Pharmacokinetics
- Patient counselling points
- Food interactions
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Questions fréquentes
What is Domperidone used for?
Domperidone is a medicine in the class gastrointestinal tract. It is used for Dyspepsia, Heartburn, Nausea & vomiting.
What side effects have been reported with Domperidone?
Headache, Dry mouth, Diarrhea, Somnolence.
Can Domperidone be taken in pregnancy or while breastfeeding?
Pregnancy: Unknown. Limited human data have not shown a rise in birth defects; high, maternally toxic doses harmed rat fetuses. UK label: use in pregnancy only when justified by the expected benefit. Better-studied antiemetics are preferred for pregnancy sickness. Breastfeeding: Safe. Very low milk levels (under 0.1% of the mother's dose) and no infant harm in published cases; it is used to boost milk supply. It carries a heart rhythm risk for the mother. UK label: decide between breastfeeding and the drug, as infant heart effects cannot be excluded.
What does Domperidone interact with?
MediHelp lists 8 known interactions for Domperidone. Contraindicated: 2 · Moderate: 5 · Minor: 1. The most serious include Azithromycin, Erythromycin, Dexlansoprazole.
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