Interactions médicamenteuses
Domperidone + Rabeprazole
Gravité: Modérée
Domperidone and Rabeprazole: moderate interaction.
Dernière mise à jour Sources: US FDA label
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Résumé
Prolonged rabeprazole therapy can cause hypomagnesemia, which together with low potassium raises the risk of QT prolongation and ventricular arrhythmia with domperidone. The effect is uncommon, typically follows months of PPI use, and matters most in older patients, those on diuretics or digoxin, and those with heart disease or other QT-prolonging drugs.
Ce que signifie cette interaction, en termes simples
Domperidone and Rabeprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Domperidone belongs to Gastrointestinal Tract; Rabeprazole belongs to Gastrointestinal Tract.
Pourquoi elle survient
Indirect pharmacodynamic: PPI-related hypomagnesemia reduces repolarisation reserve and potentiates the hERG-mediated QT prolongation of domperidone.
Conduite à tenir
Measure magnesium and potassium before starting domperidone in patients on long-term rabeprazole and correct any deficiency. Use the lowest effective domperidone dose for the shortest duration.
Questions à poser à votre pharmacien
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Références
- AcipHex (rabeprazole) Prescribing Information - Warnings: Hypomagnesemia — FDA Label
- Domperidone - Summary of Product Characteristics: Cardiac effects and QT prolongation — EMA SmPC
- PRAC recommendation: Domperidone-containing medicines - restricted use (2014) — EMA
Autres interactions de Domperidone
- Azithromycin + Domperidone Contre-indiquée
- Domperidone + Erythromycin Contre-indiquée
- Dexlansoprazole + Domperidone Modérée
- Domperidone + Lansoprazole Modérée
- Domperidone + Pantoprazole Modérée
- Domperidone + Polyethylene Glycol 3350 Modérée
Autres interactions de Rabeprazole
- Rabeprazole + Rilpivirine Contre-indiquée
- Acalabrutinib + Rabeprazole Majeure
- Atazanavir + Rabeprazole Majeure
- Dacomitinib + Rabeprazole Majeure
- Dasatinib + Rabeprazole Majeure
- Erlotinib + Rabeprazole Majeure
Questions fréquentes
Can I take Domperidone with Rabeprazole?
MediHelp rates the interaction as moderate. Domperidone and Rabeprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Prolonged rabeprazole therapy can cause hypomagnesemia, which together with low potassium raises the risk of QT prolongation and ventricular arrhythmia with domperidone. The effect is uncommon, typically follows months of PPI use, and matters most in older patients, those on diuretics or digoxin, and those with heart disease or other QT-prolonging drugs.
How serious is the interaction between Domperidone and Rabeprazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Measure magnesium and potassium before starting domperidone in patients on long-term rabeprazole and correct any deficiency. Use the lowest effective domperidone dose for the shortest duration.
What other medicines interact with Domperidone?
MediHelp also lists interactions of Domperidone with, for example, Azithromycin, Erythromycin, Dexlansoprazole. The full list is on the Domperidone page.
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