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MediHelp Référence médicamenteuse

Interactions médicamenteuses

Doxorubicin + Trastuzumab

Gravité: Majeure

Doxorubicin and Trastuzumab: major interaction.

Dernière mise à jour

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Résumé

Trastuzumab causes cardiac dysfunction, and doxorubicin causes cumulative dose-related cardiomyopathy. Combination or close sequencing markedly increases the incidence of heart failure and LVEF decline.

Ce que signifie cette interaction, en termes simples

Doxorubicin and Trastuzumab can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Doxorubicin belongs to Oncology; Trastuzumab belongs to Oncology.

Niveau de preuve: High

Pourquoi elle survient

Additive cardiotoxicity: anthracycline myocyte injury combined with inhibition of HER2-mediated cardioprotective signaling.

Conduite à tenir

Avoid concurrent use and allow a long interval after anthracycline therapy. Assess LVEF before and regularly during treatment, and withhold trastuzumab if significant decline occurs.

Questions à poser à votre pharmacien

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Doxorubicin with Trastuzumab?

MediHelp rates the interaction as major. Doxorubicin and Trastuzumab can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Trastuzumab causes cardiac dysfunction, and doxorubicin causes cumulative dose-related cardiomyopathy. Combination or close sequencing markedly increases the incidence of heart failure and LVEF decline.

How serious is the interaction between Doxorubicin and Trastuzumab?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use and allow a long interval after anthracycline therapy. Assess LVEF before and regularly during treatment, and withhold trastuzumab if significant decline occurs.

What other medicines interact with Doxorubicin?

MediHelp also lists interactions of Doxorubicin with, for example, Adenovirus types 4 and 7 live, Belatacept, Cobicistat. The full list is on the Doxorubicin page.

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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

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