Aller au contenu
MediHelp
MediHelp Référence médicamenteuse

Interactions médicamenteuses

Idarubicin + Trastuzumab

Gravité: Majeure

Idarubicin and Trastuzumab: major interaction.

Dernière mise à jour

Réservé aux professionnels de santé — à titre de référence uniquement. Cette page est un bref résumé, pas un avis médical, et ne remplace ni la notice officielle ni le jugement clinique. Vérifiez toujours avant de prescrire ou de délivrer.

Le contenu clinique de cette page n'est disponible qu'en anglais.

Résumé

Trastuzumab-associated cardiomyopathy is more frequent and severe when combined with or given after anthracyclines. Idarubicin shares the cardiotoxic class effect, so the combination carries a significant risk of heart failure.

Ce que signifie cette interaction, en termes simples

Idarubicin and Trastuzumab can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Idarubicin belongs to Oncology; Trastuzumab belongs to Oncology.

Niveau de preuve: Moderate

Pourquoi elle survient

Additive cardiotoxicity from anthracycline myocyte damage and HER2 signaling blockade.

Conduite à tenir

Avoid concurrent use where possible and check LVEF at baseline and regularly. Stop or hold treatment if LVEF drops or heart failure develops.

Questions à poser à votre pharmacien

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

Réservé aux membres Pro+

Débloquer la page complète

Créez un compte et lancez un essai Pro+ pour débloquer les conseils complets de prise en charge pour Idarubicin et Trastuzumab, les notes complémentaires, le détail des données probantes et le vérificateur d'interactions pour une ordonnance complète.

  • Full clinical management advice
  • Additional notes
  • Evidence detail
  • Interaction checker for a whole prescription
Créer un compte gratuit Se connecter

Essayez Pro+ gratuitement pendant 7 jours sur le web. Sans carte.

Questions fréquentes

Can I take Idarubicin with Trastuzumab?

MediHelp rates the interaction as major. Idarubicin and Trastuzumab can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Trastuzumab-associated cardiomyopathy is more frequent and severe when combined with or given after anthracyclines. Idarubicin shares the cardiotoxic class effect, so the combination carries a significant risk of heart failure.

How serious is the interaction between Idarubicin and Trastuzumab?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use where possible and check LVEF at baseline and regularly. Stop or hold treatment if LVEF drops or heart failure develops.

What other medicines interact with Idarubicin?

MediHelp also lists interactions of Idarubicin with, for example, Adenovirus types 4 and 7 live, Belatacept, Cyclophosphamide. The full list is on the Idarubicin page.

Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp

Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

Télécharger surApp Store Disponible surGoogle Play

Parcourir de A à Z · Interactions médicamenteuses

Télécharger l'app Se connecter