Interactions médicamenteuses
Daunorubicin + Trastuzumab
Gravité: Majeure
Daunorubicin and Trastuzumab: major interaction.
Dernière mise à jour
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Résumé
Trastuzumab causes cardiac dysfunction, and anthracyclines such as daunorubicin cause cumulative dose-related cardiomyopathy. Used together or in close sequence, the risk of symptomatic heart failure and reduced ejection fraction is clearly higher than with either drug alone.
Ce que signifie cette interaction, en termes simples
Daunorubicin and Trastuzumab can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Daunorubicin belongs to Oncology; Trastuzumab belongs to Oncology.
Pourquoi elle survient
Additive cardiotoxicity: anthracycline myocyte injury combined with impaired HER2-dependent cardiomyocyte survival signaling.
Conduite à tenir
Avoid concurrent use where possible and keep a long interval between anthracycline and trastuzumab. Assess LVEF before and regularly during treatment, and stop trastuzumab if significant decline occurs.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Autres interactions de Daunorubicin
- Adenovirus types 4 and 7 live + Daunorubicin Contre-indiquée
- Belatacept + Daunorubicin Majeure
- Cyclosporine + Daunorubicin Majeure
- Cyclosporin + Daunorubicin Majeure
- Daunorubicin + Dengue vaccine Majeure
- Daunorubicin + Etrasimod Majeure
Autres interactions de Trastuzumab
- Doxorubicin liposomal + Trastuzumab Majeure
- Doxorubicin + Trastuzumab Majeure
- Epirubicin + Trastuzumab Majeure
- Idarubicin + Trastuzumab Majeure
- Liposomal doxorubicin + Trastuzumab Majeure
- Mitoxantrone + Trastuzumab Majeure
Questions fréquentes
Can I take Daunorubicin with Trastuzumab?
MediHelp rates the interaction as major. Daunorubicin and Trastuzumab can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Trastuzumab causes cardiac dysfunction, and anthracyclines such as daunorubicin cause cumulative dose-related cardiomyopathy. Used together or in close sequence, the risk of symptomatic heart failure and reduced ejection fraction is clearly higher than with either drug alone.
How serious is the interaction between Daunorubicin and Trastuzumab?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use where possible and keep a long interval between anthracycline and trastuzumab. Assess LVEF before and regularly during treatment, and stop trastuzumab if significant decline occurs.
What other medicines interact with Daunorubicin?
MediHelp also lists interactions of Daunorubicin with, for example, Adenovirus types 4 and 7 live, Belatacept, Cyclosporine. The full list is on the Daunorubicin page.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
