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Interactions médicamenteuses

Epirubicin + Trastuzumab

Gravité: Majeure

Epirubicin and Trastuzumab: major interaction.

Dernière mise à jour

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Résumé

Concurrent or sequential use of trastuzumab with anthracyclines such as epirubicin increases the incidence and severity of cardiomyopathy. Heart failure may develop and be clinically significant.

Ce que signifie cette interaction, en termes simples

Epirubicin and Trastuzumab can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Epirubicin belongs to Oncology; Trastuzumab belongs to Oncology.

Niveau de preuve: High

Pourquoi elle survient

Additive cardiotoxicity from anthracycline injury and HER2 pathway inhibition.

Conduite à tenir

Avoid concurrent use outside protocols with strict cardiac surveillance. Check LVEF at baseline and periodically, and hold therapy if LVEF declines significantly.

Questions à poser à votre pharmacien

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Epirubicin with Trastuzumab?

MediHelp rates the interaction as major. Epirubicin and Trastuzumab can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Concurrent or sequential use of trastuzumab with anthracyclines such as epirubicin increases the incidence and severity of cardiomyopathy. Heart failure may develop and be clinically significant.

How serious is the interaction between Epirubicin and Trastuzumab?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use outside protocols with strict cardiac surveillance. Check LVEF at baseline and periodically, and hold therapy if LVEF declines significantly.

What other medicines interact with Epirubicin?

MediHelp also lists interactions of Epirubicin with, for example, Adenovirus types 4 and 7 live, Belatacept, Cimetidine. The full list is on the Epirubicin page.

Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp

Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

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