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MediHelp Référence médicamenteuse

Interactions médicamenteuses

Mitoxantrone + Trastuzumab

Gravité: Majeure

Mitoxantrone and Trastuzumab: major interaction.

Dernière mise à jour

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Résumé

Trastuzumab combined with an anthracenedione such as mitoxantrone increases the risk of heart failure and reduced left ventricular ejection fraction. Neutropenia may also be more frequent when trastuzumab is added to myelosuppressive chemotherapy.

Ce que signifie cette interaction, en termes simples

Mitoxantrone and Trastuzumab can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Mitoxantrone belongs to Central Nervous System; Trastuzumab belongs to Oncology.

Niveau de preuve: Moderate

Pourquoi elle survient

Additive cardiotoxicity from HER2 inhibition of cardiomyocyte survival signalling combined with mitoxantrone's direct myocardial damage; additive myelosuppression also contributes.

Conduite à tenir

Avoid concurrent use where possible. Assess LVEF before and periodically during therapy and monitor neutrophil counts.

Questions à poser à votre pharmacien

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Mitoxantrone with Trastuzumab?

MediHelp rates the interaction as major. Mitoxantrone and Trastuzumab can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Trastuzumab combined with an anthracenedione such as mitoxantrone increases the risk of heart failure and reduced left ventricular ejection fraction. Neutropenia may also be more frequent when trastuzumab is added to myelosuppressive chemotherapy.

How serious is the interaction between Mitoxantrone and Trastuzumab?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use where possible. Assess LVEF before and periodically during therapy and monitor neutrophil counts.

What other medicines interact with Mitoxantrone?

MediHelp also lists interactions of Mitoxantrone with, for example, Adenovirus types 4 and 7 live, Axicabtagene ciloleucel, Belatacept. The full list is on the Mitoxantrone page.

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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

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