Interactions médicamenteuses
Doxorubicin liposomal + Trastuzumab
Gravité: Majeure
Doxorubicin liposomal and Trastuzumab: major interaction.
Dernière mise à jour
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Résumé
Trastuzumab can cause left ventricular dysfunction and heart failure, and the risk is greatest when it is given with or soon after anthracyclines. Liposomal doxorubicin is less cardiotoxic than conventional doxorubicin but still adds cardiac risk.
Ce que signifie cette interaction, en termes simples
Doxorubicin liposomal and Trastuzumab can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Pourquoi elle survient
Additive cardiotoxicity: anthracycline myocyte injury combined with impaired HER2-dependent cardiomyocyte repair from trastuzumab.
Conduite à tenir
Avoid the combination if possible. If it is used, assess left ventricular ejection fraction before and at regular intervals during treatment, and stop trastuzumab for significant decline.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Autres interactions de Trastuzumab
- Daunorubicin + Trastuzumab Majeure
- Doxorubicin + Trastuzumab Majeure
- Epirubicin + Trastuzumab Majeure
- Idarubicin + Trastuzumab Majeure
- Liposomal doxorubicin + Trastuzumab Majeure
- Mitoxantrone + Trastuzumab Majeure
Questions fréquentes
Can I take Doxorubicin liposomal with Trastuzumab?
MediHelp rates the interaction as major. Doxorubicin liposomal and Trastuzumab can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Trastuzumab can cause left ventricular dysfunction and heart failure, and the risk is greatest when it is given with or soon after anthracyclines. Liposomal doxorubicin is less cardiotoxic than conventional doxorubicin but still adds cardiac risk.
How serious is the interaction between Doxorubicin liposomal and Trastuzumab?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible. If it is used, assess left ventricular ejection fraction before and at regular intervals during treatment, and stop trastuzumab for significant decline.
What other medicines interact with Trastuzumab?
MediHelp also lists interactions of Trastuzumab with, for example, Daunorubicin, Doxorubicin, Epirubicin. The full list is on the Trastuzumab page.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
